The impact of genetic background and Bid on the phenotype of Bcl-2-deficiency in mice.

doi:10.1007/s10495-007-0147-8

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Article

The impact of genetic background and Bid on the phenotype of Bcl-2-deficiency in mice.

Apoptosis : an international journal on programmed cell death - 1 Jan 2008

Ni Hong-Min, Chen Xiaoyun, Chen Lei, DiFrancesca Daniell, Harada Hisashi, Yin Xiao-Ming

Abstract excerpt

How a central apoptosis mechanism could be modulated during a specific developmental or homeostatic process to comply with the specific needs of a particular tissue is poorly understood. Bcl-2 is a key anti-apoptosis regulator and its deletion resulted in multiple defects in mice, indicating its broad involvement in development and homeostasis of various tissues. We found that the severity and extensiveness of...

Topics

Animals
Apoptosis
BH3 Interacting Domain Death Agonist Protein
Lymphopenia
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Phenotype
Polycystic Kidney Diseases
Proto-Oncogene Proteins c-bcl-2

Source

Open in PubMed

Identifiers

PMID: 17955375
DOI: 10.1007/s10495-007-0147-8

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