Article
Effect of p53 Arg72Pro polymorphism on the induction of micronucleus by aflatoxin B1 in in vitro in human blood lymphocytes.
Drug and chemical toxicology - 1 Jan 2016
Bayram Süleyman, Rencüzoğulları Eyyüp, Almas Abdullah Muttalip, Genç Ahmet
Abstract excerpt
Aflatoxin B1 (AFB1) is a class 1 carcinogen produced by Aspergillus flavus and Aspergillus parasiticus that can contaminate a variety of food substances, the liver being its target organ. A common p53 Arg72Pro polymorphism resulting in the substitution of an arginine amino acid by proline amino acid in the transactivating domain has been demonstrated to affect p53 function. The aim of this study is to investigate...
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