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Article

Bcl-3 promotes multi-modal tumour cell migration via NF-κB1 mediated regulation of Cdc42

15 Jan 2020

Abstract excerpt

A key challenge in the implementation of anti-metastatics as cancer therapies is the multi-modal nature of cell migration, which allows tumour cells to evade the targeted inhibition of specific cell motility pathways. The nuclear factor-kappaB (NF-κB) co-factor B-cell lymphoma 3 (Bcl-3) has been implicated in breast cancer cell migration and metastasis, yet it remains to be determined exactly which cell motility...

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PMID: 31957805
DOI: 10.1093/carcin/bgaa005

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