Article
Evolution of the proteinase inhibitor I family and apparent lack of hypervariability in the proteinase contact loop.
Journal of molecular evolution - 1 Dec 1994
Beuning L L, Spriggs T W, Christeller J T
Abstract excerpt
A protein phylogenetic tree was constructed from 24 homologous proteinase inhibitor I sequences identified in the EMBL/Genbank and Swiss-Prot databases and from translated amino acid data from four constitutive cDNA clones of proteinase inhibitor I characterized from potato tuber mRNA. The tree suggests that divergence of at least four paralogous proteins with functional specialization occurred at different times...
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