Article

Meta-analysis of genome-wide association studies of doxorubicin-induced arrhythmia identifies <i>MMP16 and KCTD15 as risk loci</i>

2025-12-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Anthracyclines are a widely used and effective class of chemotherapy. However, a major limitation for their use is cardiotoxicity, manifesting as systolic dysfunction, congestive heart failure (HF) and arrhythmias. <h4>Objective</h4> Identify genes and genetic risk variants for doxorubicin-induced arrhythmia. <h4>Methods</h4> We performed genome-wide association studies (G...

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Literature Corpus work: f2e7864e-3174-5c48-b5ac-e902b30f28af
DOI: 10.64898/2025.12.16.25342433

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