Article
Alternative splicing generates a smaller assortment of CaV2.1 transcripts in cerebellar Purkinje cells than in the cerebellum.
Physiological genomics - 12 Jan 2006
Kanumilli Srinivasan, Tringham Elizabeth W, Payne C Elizabeth, Dupere Jonathan R B, Venkateswarlu Kanamarlapudi, Usowicz Maria M
Abstract excerpt
P/Q-type calcium channels control many calcium-driven functions in the brain. The CACNA1A gene encoding the pore-forming CaV2.1 (alpha1A) subunit of P/Q-type channels undergoes alternative splicing at multiple loci. This results in channel variants with different phenotypes. However, the combinatorial patterns of alternative splice events at two or more loci, and hence the diversity of CaV2.1 transcripts, are...
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