Tumor necrosis factor and interferon gamma: relevance for immune regulation and genetic predisposition to autoimmune disease.

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Article

Tumor necrosis factor and interferon gamma: relevance for immune regulation and genetic predisposition to autoimmune disease.

Seminars in immunology - 1 Jun 1992

Jacob C O

Abstract excerpt

The role of TNF-alpha and IFN-gamma in various models of autoimmune disease were analyzed. These include murine models of lupus, type 1 diabetes in NOD mice and the adjuvant arthritis model in rats. Rather than being involved mainly in the effector arm of the inflammatory process of autoimmune or...

Topics

Animals
Arthritis, Experimental
Arthritis, Rheumatoid
Autoimmune Diseases
Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 1
Disease Models, Animal
Gene Expression Regulation
Genes, MHC Class II
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immune System

Interferon-gamma

Lupus Erythematosus, Systemic

Mice

Mice, Inbred Strains

Mice, Mutant Strains

Rats

Source

Open in PubMed

Identifiers

PMID: 1627786

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1627786-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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