Article
TNF, apoptosis and autoimmunity: a common thread?
Blood cells, molecules & diseases - 1 Jun 1998
Beutler B, Bazzoni F
Abstract excerpt
A subset of cytokine mediators belonging to the tumor necrosis factor (TNF) family cause apoptosis, acting through receptors and signaling pathways that have recently come to light. Further, at least one autoimmune disease results from a defined defect of apoptosis (mutations of the Fas ligand or...
Topics
- Apoptosis
- Autoimmune Diseases
- Autoimmunity
- DNA-Binding Proteins
- Dimerization
- Fas Ligand Protein
- Gene Expression Regulation
- Membrane Glycoproteins
- Models, Immunological
- Multigene Family
- Phenotype
- Protein Structure, Tertiary
- Receptors, Tumor Necrosis Factor
- Signal Transduction
- Structure-Activity Relationship
- Tumor Necrosis Factor-alpha
- Zinc Fingers