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Article

Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.

Cancer discovery - 1 Oct 2012

Harbinski Fred, Craig Vanessa J, Sanghavi Sneha, Jeffery Douglas, Liu Lijuan, Sheppard Kelly Ann, Wagner Sabrina, Stamm Christelle, Buness Andreas, Chatenay-Rivauday Christian, Yao Yao, He Feng, Lu Chris X, Guagnano Vito, Metz Thomas, Finan Peter M, Hofmann Francesco, Sellers William R, Porter Jeffrey A, Myer Vic E, Graus-Porta Diana, Wilson Christopher J, Buckler Alan, Tiedt Ralph

Abstract excerpt

The overall power of kinase inhibitors is substantially overshadowed by the acquisition of drug resistance. To address this issue, we systematically assessed the potential of secreted proteins to induce resistance to kinase inhibitors. To this end, we developed a high-throughput platform for scre...

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Share to Drug Resistance, Neoplasm
Share to High-Throughput Screening Assays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins c-met

Share to Receptor, ErbB-2

Share to Receptor, Fibroblast Growth Factor, Type 2

Share to Receptor, Fibroblast Growth Factor, Type 3

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 22874768
DOI: 10.1158/2159-8290.CD-12-0237

Genes

MET
FGFR2
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22874768-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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