Virulent clinical isolates of <i>Mycobacterium tuberculosis</i> grow rapidly and induce cellular necrosis but minimal apoptosis in murine macrophages

Abstract excerpt

In this study, we investigated the ability of four clinical isolates of Mycobacterium tuberculosis representing a range of virulence for their capacity to grow in bone marrow-derived macrophages. The rate of growth of each of the isolates in macrophages reflected their known virulence, but the most virulent isolates strongly induced production of the cytokine tumor necrosis factor alpha. A key difference,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Infectious Diseases and Tuberculosis
• Share to Mycobacterium research and diagnosis
• Share to Tuberculosis Research and Epidemiology