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Article

Apoptosis Genes in Human Alveolar Macrophages Infected with Virulent or Attenuated <i>Mycobacterium tuberculosis</i>

19 May 2003

Abstract excerpt

Tumor necrosis factor (TNF)-alpha-dependent apoptosis of alveolar macrophages (AM) after infection with avirulent Mycobacterium tuberculosis (Mtb) results in bacillary death and the destruction of a growth niche for the pathogen. This response is minimized after infection with virulent strains of Mtb. To study the genetic control of Mtb-induced apoptosis, we used microarrays to interrogate the expression profile...

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PMID: 12748057
DOI: 10.1165/rcmb.2002-0310oc

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