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Article

Genomic buffering mitigates the effects of deleterious mutations in bacteria.

Nature genetics - 1 Dec 2005

Maisnier-Patin Sophie, Roth John R, Fredriksson Asa, Nyström Thomas, Berg Otto G, Andersson Dan I

Abstract excerpt

The relationship between the number of randomly accumulated mutations in a genome and fitness is a key parameter in evolutionary biology. Mutations may interact such that their combined effect on fitness is additive (no epistasis), reinforced (synergistic epistasis) or mitigated (antagonistic epistasis). We measured the decrease in fitness caused by increasing mutation number in the bacterium Salmonella...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16273106
DOI: 10.1038/ng1676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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