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Article

Structural insights into the asymmetric effects of zinc-ligand cysteine mutations in the novel zinc ribbon domain of human TFIIEalpha for transcription.

Journal of biochemistry - 1 Oct 2005

Okuda Masahiko, Tanaka Aki, Hanaoka Fumio, Ohkuma Yoshiaki, Nishimura Yoshifumi

Abstract excerpt

The large subunit of TFIIE (TFIIEalpha) has a highly conserved zinc ribbon domain, which is essential for transcription. Recently, we determined the solution structure of this domain to be that of a novel zinc finger motif [Okuda et al. (2004) J. Biol. Chem. 279, 51395-51403]. On examination of the functions of four cysteine mutants of TFIIEalpha, in which each of four zinc-liganded cysteines was replaced by...

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PMID: 16272138
DOI: 10.1093/jb/mvi138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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