Polymorphisms of -174G>C and -572G>C in the interleukin 6 (IL-6) gene and coronary heart disease risk: a meta-analysis of 27 research studies.

doi:10.1371/journal.pone.0034839

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Article

Polymorphisms of -174G>C and -572G>C in the interleukin 6 (IL-6) gene and coronary heart disease risk: a meta-analysis of 27 research studies.

PloS one - 1 Jan 2012

Zheng Guo-hua, Chen Hai-ying, Xiong Shang-Quan

Abstract excerpt

OBJECTIVE: Elevated serum IL-6 level is a risk factor for coronary heart disease (CHD). The -174 G>C and -572 G>C polymorphisms in the IL-6 gene have previously been shown to modulate IL-6 levels. But the association between the -174 G>C and -572 G>C polymorphisms and the risk of CHD is still unclear. A meta-analysis of all eligible studies was carried out to clarify the role of IL-6 gene polymorphisms in CHD....

Topics

Coronary Disease
Databases, Genetic
Gene Frequency
Genetic Association Studies
Humans
Interleukin-6
Mutation
Polymorphism, Genetic
PubMed
Risk

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Identifiers

PMID: 22509361
DOI: 10.1371/journal.pone.0034839
PMCID: PMC3324545

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