Article
The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain.
Journal of cellular biochemistry - 1 Mar 2006
Peng Cong, Zhou Jie, Liu Hua Ying, Zhou Ming, Wang Li Li, Zhang Qiu Hong, Yang Yi Xin, Xiong Wei, Shen Shou Rong, Li Xiao Ling, Li Gui Yuan
Abstract excerpt
Studies showed that the bromodomain binds to acetyl-lysines on histone tails, which is involved in deciphering the histone codes. BRD7, a novel bromodomain gene, is the first described bromodomain gene involved in nasopharyngeal carcinoma (NPC). Previous studies showed that ectopic expression of BRD7 inhibited cell growth and cell cycle progression from G1 to S phase in HNE1 cells (a NPC cell line) by...
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