Article
[Current views of thalassemia intermedia].
Recenti progressi in medicina - 1 Apr 1992
Longinotti M, Dore F, Oggiano L, Pardini S, Pistidda P, Guiso L, Frogheri L, Bonfigli S, Murineddu M, Rimini E
Abstract excerpt
Recently the molecular bases of thalassemia intermedia have been elucidated in several populations. In general this attenuated, non-transfusion dependent form of homozygous beta-thalassemia is mainly determined by a) the co-inheritance of deletion alpha-thalassemia; b) the presence of the so-called mild beta-thalassemia mutations; and more rarely, c) the inheritance of genetic conditions able to enhance the...
Topics
- Base Sequence
- Hemoglobins, Abnormal
- Heterozygote
- Homozygote
- Humans
- Italy
- Molecular Sequence Data
- Mutation
- Pedigree
- Thalassemia