Article
Phenotypes of individuals with a beta thal classical allele associated either with a beta thal silent allele or with alpha globin gene triplication.
Haematologica - 1 Jan 2000
Bianco I, Lerone M, Foglietta E, Deidda G, Cappabianca M P, Morlupi L, Ponzini D, Grisanti P, Di Biagio P, Amato A, Mezzabotta M, Graziani B
Abstract excerpt
BACKGROUND AND OBJECTIVE: beta thalassemia intermedia has its origins in compound heterozygosity for many different beta thal defects or in an interaction of a beta thal defect with altered alpha cluster. Two specific genetic associations (beta thal/beta(+) -101 C-->T and beta thal + alpha alpha alpha or alpha alpha alpha alpha) have been described in recent years as being determining a phenotype similar to that...
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