Thalassemia intermedia: compound heterozygous beta zero/beta(+)-thalassemia and co-inherited heterozygous alpha(+)-thalassemia.

doi:10.1007/BF01737689

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Article

Thalassemia intermedia: compound heterozygous beta zero/beta(+)-thalassemia and co-inherited heterozygous alpha(+)-thalassemia.

Annals of hematology - 1 Jan 1993

Kulozik A E, Kohne E, Kleihauer E

Abstract excerpt

The relative excess of alpha- over beta-globin chains in the erythroid precursors is the chief pathophysiological factor of homozygous beta-thalassemia. The clinical picture is usually characterized by a transfusion-dependent dyserythropoietic anemia (thalassemia major). However, some patients pr...

Topics

Base Sequence
Child
Female
Genotype
Globins
Haploidy
Heterozygote
Humans
Molecular Sequence Data
beta-Thalassemia

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