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Article

Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils.

Protein science : a publication of the Protein Society - 1 Dec 2005

Galea Charles, Bowman Prentice, Kriwacki Richard W

Abstract excerpt

We describe in molecular detail how disruption of an intermonomer salt bridge (Arg337-Asp352) leads to partial destabilization of the p53 tetramerization domain and a dramatically increased propensity to form amyloid fibrils. At pH 4.0 and 37 degrees C, a p53 tetramerization domain mutant (p53tet-R337H), associated with adrenocortical carcinoma in children, readily formed amyloid fibrils, while the wild-type...

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Identifiers

PMID: 16260757
DOI: 10.1110/ps.051622005
PMCID: PMC2253254

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Source receipt: pubmed, retrieved 7 Sept 2026.

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