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Article

A nuclear surveillance pathway for mRNAs with defective polyadenylation.

Molecular and cellular biology - 1 Nov 2005

Milligan Laura, Torchet Claire, Allmang Christine, Shipman Tracey, Tollervey David

Abstract excerpt

The pap1-5 mutation in poly(A) polymerase causes rapid depletion of mRNAs at restrictive temperatures. Residual mRNAs are polyadenylated, indicating that Pap1-5p retains at least partial activity. In pap1-5 strains lacking Rrp6p, a nucleus-specific component of the exosome complex of 3'-5' exonuc...

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Identifiers

PMID: 16260613
DOI: 10.1128/MCB.25.22.9996-10004.2005
PMCID: PMC1280253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16260613-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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