Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

-511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone.

Bone - 1 Apr 2006

Corral-Gudino Luis, del Pino-Montes Javier, García-Aparicio Judit, Corral Esther, Montilla Carlos A, González-Sarmiento Rogelio

Abstract excerpt

INTRODUCTION: Osteoclasts are the most important cells involved in the pathogenesis of Paget disease of bone (PDB). Cytokines stimulate osteoclast differentiation and activation, with some of them over-expressed in pagetic osteoclasts. We have assessed whether genetic variability in genes coding of proteins from the IL1 pathway clustered in chromosome 2 is associated with clinical characteristics and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diphosphonates
Share to Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Interleukin-1

Share to Osteitis Deformans

Share to Polymerase Chain Reaction

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Source

Identifiers

PMID: 16257277
DOI: 10.1016/j.bone.2005.09.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

-511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone.PMID 16257277Read ↗

Paget's disease of bone is not associated with common polymorphisms in interleukin-6, interleukin-8 and tumor necrosis factor alpha genes.Semantic proximity Read ↗

Proinflammatory cytokine gene polymorphisms and susceptibility to Paget's disease of bone: an association study.Semantic proximity Read ↗

Genetic polymorphisms in IL1B predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese Han populationSemantic proximity Read ↗

Influence of a polymorphism IL1B gene in the response of rheumatoid arthritis and ankylosing spondylitis patients treated with infliximabSemantic proximity Read ↗

Indications for a genetic association of a VCP polymorphism with the pathogenesis of sporadic Paget's disease of bone, but not for TNFSF11 (RANKL) and IL-6 polymorphisms.Semantic proximity Read ↗

Susceptibility to Paget's disease of bone is influenced by a common polymorphic variant of osteoprotegerin.Semantic proximity Read ↗

Genetic variation in the TNFRSF11A gene encoding RANK is associated with susceptibility to Paget's disease of bone.Semantic proximity Read ↗

Identification of sex-specific associations between polymorphisms of the osteoprotegerin gene, TNFRSF11B, and Paget's disease of bone.Semantic proximity Read ↗

Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip.Semantic proximity Read ↗

Hip osteoarthritis susceptibility is associated with IL1B -511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian Caucasian population.Semantic proximity Read ↗

Interleukin-1α gene variants influence bone mineral density and the risk of osteoporotic hip fractures in elderly Slovenian people.Semantic proximity Read ↗

Association of interleukin-1 beta (-511C/T) polymorphisms with osteoporosis in postmenopausal women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.