Article
Identification of sex-specific associations between polymorphisms of the osteoprotegerin gene, TNFRSF11B, and Paget's disease of bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2007
Beyens Greet, Daroszewska Anna, de Freitas Fenna, Fransen Erik, Vanhoenacker Filip, Verbruggen Leon, Zmierczak Hans-Georg, Westhovens René, Van Offel Jan, Ralston Stuart H, Devogelaer Jean-Pierre, Van Hul Wim
Abstract excerpt
UNLABELLED: We studied the role of TNFRSF11B polymorphisms on the risk to develop Paget's disease of bone in a Belgian study population. We observed no association in men, but a highly significant association was found in women, and this was confirmed in a population from the United Kingdom. INTRODUCTION: Juvenile Paget's disease has been shown to be caused by mutations in TNFRSF11B encoding osteoprotegerin....
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