Article
HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia).
Clinical immunology (Orlando, Fla.) - 1 Jan 2006
Vacek Marla M, Schäffer Alejandro A, Davis Joie, Fischer Roxanne E, Dale Janet K, Adams Sharon, Straus Stephen E, Puck Jennifer M
Abstract excerpt
Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte apoptosis characterized by non-malignant lymphadenopathy and splenomegaly, expansion of T cells without either CD4 or CD8 surface markers, and increased incidence of autoimmune diseases and lymphoma. Most patients with ALPS have dominant, heterozygous mutations in tumor necrosis factor receptor superfamily member 6 (TNFRSF6), which encodes...
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