Article
Clinical, immunological, and genetic features in 780 patients with autoimmune lymphoproliferative syndrome (ALPS) and ALPS-like diseases: A systematic review.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Oct 2021
Hafezi Nasim, Zaki-Dizaji Majid, Nirouei Matineh, Asadi Gelayol, Sharifinejad Niusha, Jamee Mahnaz, Erfan Rasouli Seyed, Hamedifar Haleh, Sabzevari Araz, Chavoshzadeh Zahra, Yazdani Reza, Abolhassani Hassan, Aghamohammadi Asghar, Azizi Gholamreza
Abstract excerpt
BACKGROUND: Autoimmune lymphoproliferative syndrome (ALPS) is a group of genetic disorders characterized by early-onset lymphoproliferation, autoimmune cytopenias, and susceptibility to lymphoma. The majority of ALPS patients carry heterozygous germline mutations in the TNFRSF6 gene. In this study, we conducted a systematic review of patients with ALPS and ALPS-like syndrome. METHODS: The literature search was...
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