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Article

Autoimmune Lymphoproliferative Syndrome (ALPS)

1 Jan 2003

Abstract excerpt

In patients with ALPS, defective homeostasis of lymphocytes is reflected in abnormal accumulation of lymphocytes, leading to lymphadenopathy, (hepato)splenomegaly and hypersplenism, autoimmunity due to a failure to remove autoreactive lymphocytes, and inappropriate survival of lymphocytes associated with an increased occurrence of lymphoma. Several of the laboratory findings are unique for ALPS and reflect...

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Identifiers

PMID: 12570831
DOI: 10.2174/1381612033392107

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