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Article

Concurrent depletion of Vps37 proteins evokes ESCRT-I destabilization and profound cellular stress responses

1 Jan 2021

Abstract excerpt

ABSTRACT Molecular details of how endocytosis contributes to oncogenesis remain elusive. Our in silico analysis of colorectal cancer (CRC) patients revealed stage-dependent alterations in the expression of 112 endocytosis-related genes. Among them, transcription of the endosomal sorting complex required for transport (ESCRT)-I component VPS37B was decreased in the advanced stages of CRC. Expression of other...

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PMID: 33419951
DOI: 10.1242/jcs.250951

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