Article
Polymorphisms of the DNA mismatch repair gene HMSH2 in breast cancer occurence and progression.
Breast cancer research and treatment - 1 Dec 2005
Poplawski Tomasz, Zadrozny Marek, Kolacinska Agnieszka, Rykala Jan, Morawiec Zbigniew, Blasiak Janusz
Abstract excerpt
The response of the cell to DNA damage and its ability to maintain genomic stability by DNA repair are crucial in preventing cancer initiation and progression. Therefore, polymorphism of DNA repair genes may affect the process of carcinogenesis. The importance of genetic variability of the components of mismatch repair (MMR) genes is well documented in colorectal cancer, but little is known about its role in...
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