Article
Polymorphism of DNA mismatch repair genes in endometrial cancer.
Experimental oncology - 1 Mar 2015
Poplawski T, Sobczuk A, Sarnik J, Pawlowska E, Blasiak J
Abstract excerpt
UNLABELLED: Endometrial cancer (EC) is the second most common malignancy associated with hereditary non-polyposis colorectal cancer (HNPCC) family. The development of HNPCC is associated with defects in DNA mismatch repair (MMR) pathway resulting in microsatellite instability (MSI). MSI is present in a greater number of EC than can be accounted for by inherited MMR mutations, therefore alternative mechanisms may...
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