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Article

Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis.

Cell - 16 Dec 2005

Hill Reginald, Song Yurong, Cardiff Robert D, Van Dyke Terry

Abstract excerpt

Our understanding of cancer has largely come from the analysis of aberrations within the tumor cell population. Yet it is increasingly clear that the tumor microenvironment can significantly influence tumorigenesis. For example, the mesenchyme can support the growth of tumorigenic epithelium. However, whether fibroblasts are subject to genetic/epigenetic changes as a result of selective pressures conferred by...

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Identifiers

PMID: 16360031
DOI: 10.1016/j.cell.2005.09.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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