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Article

Susceptibilities of antiviral-resistant influenza viruses to novel neuraminidase inhibitors.

Antimicrobial agents and chemotherapy - 1 Nov 2005

Mishin Vasiliy P, Hayden Frederick G, Gubareva Larisa V

Abstract excerpt

The susceptibilities of five zanamivir-resistant and six oseltamivir-resistant influenza viruses were assessed against four neuraminidase (NA) inhibitors, including peramivir and A-315675, by a fluorometric NA activity inhibition assay. The enzyme activity of a majority of the variants was effectively inhibited by either A-315675 or both peramivir and A-315675 (50% inhibitory concentration, <10 nM). A novel...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16251290
DOI: 10.1128/AAC.49.11.4515-4520.2005
PMCID: PMC1280118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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