Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.

The Journal of biological chemistry - 22 Nov 2002

Sinha Suwan K, Zachariah Sunny, Quiñones Herson I, Shindo Masahisa, Chaudhary Preet M

Abstract excerpt

X-linked ectodermal dysplasia receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). By using a subclone of 293F cells with stable expression of XEDAR, we report that XEDAR activates the NF-kappaB and JNK pathways in an EDA-A2-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ectodermal Dysplasia
Share to Ectodysplasins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Edar Receptor

Share to I-kappa B Proteins

Share to JNK Mitogen-Activated Protein Kinases

Share to NF-KappaB Inhibitor alpha

Share to Receptors, Tumor Necrosis Factor

Share to TNF Receptor-Associated Factor 6

Source

Identifiers

PMID: 12270937
DOI: 10.1074/jbc.M207923200

Genes

TRAF3
EDA
TRAF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.PMID 12270937Read ↗

TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.Semantic proximity Read ↗

Ectodysplasin signaling in development.Semantic proximity Read ↗

Functional studies for the TRAF6 mutation associated with hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice.Semantic proximity Read ↗

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.Semantic proximity Read ↗

The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.Semantic proximity Read ↗

Ectodysplasin A protein promotes corneal epithelial cell proliferationSemantic proximity Read ↗

Different degree of loss-of-function among four missense mutations in the EDAR gene responsible for autosomal recessive hypohidrotic ectodermal dysplasia may be associated with the phenotypic severity.Semantic proximity Read ↗

TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways.Semantic proximity Read ↗

Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.Semantic proximity Read ↗

Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.