Article
Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat.
Hepatology (Baltimore, Md.) - 1 Nov 2005
Benten Daniel, Kumaran Vinay, Joseph Brigid, Schattenberg Jörn, Popov Yury, Schuppan Detlef, Gupta Sanjeev
Abstract excerpt
We investigated whether transplanted hepatocytes interact with hepatic stellate cells, as cell-cell interactions could modulate their engraftment in the liver. We transplanted Fischer 344 rat hepatocytes into syngeneic dipeptidyl peptidase IV-deficient rats. Activation of hepatic stellate cells w...
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