Article
Sirolimus and tacrolimus trough concentrations and dose requirements after kidney transplantation in relation to CYP3A5 and MDR1 polymorphisms and steroids.
Transplantation - 15 Oct 2005
Mourad Michel, Mourad Georges, Wallemacq Pierre, Garrigue Valérie, Van Bellingen Christophe, Van Kerckhove Valérie, De Meyer Martine, Malaise Jacques, Eddour Djamila Chaib, Lison Dominique, Squifflet Jean Paul, Haufroid Vincent
Abstract excerpt
BACKGROUND: CYP3A5 and MDR1 polymorphisms have been shown to influence tacrolimus blood concentrations and dose requirements. The aim is to determine whether these polymorphisms also affect sirolimus trough concentrations and dose requirements after kidney transplantation. METHODS: Eighty-five renal transplant recipients receiving sirolimus were included. Twenty-four were treated with a combined...
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