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Article

Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Mar 2005

Anglicheau Dany, Le Corre Delphine, Lechaton Sophie, Laurent-Puig Pierre, Kreis Henri, Beaune Philippe, Legendre Christophe, Thervet Eric

Abstract excerpt

Sirolimus (SRL) is a substrate for cytochromes P-450 3A and P-glycoprotein, the product of the MDR1 gene. We postulated that single nucleotide polymorphisms (SNPs) of these genes could be associated with inter-individual variations in SRL requirements. We then evaluated in 149 renal transplant recipients the effect of polymorphisms CYP3A4*1/*1B, CYP3A5*1/*3 and MDR1 SNPs in exon 12, 21 and 26 on SRL...

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Source

Identifiers

PMID: 15707415
DOI: 10.1111/j.1600-6143.2005.00745.x

Genes

SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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