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Article

Characteristics of embryonic stem cell differentiation: a comparison with two embryonal carcinoma cell lines.

Cell differentiation and development : the official journal of the International Society of Developmental Biologists - 1 Jun 1990

Mummery C L, Feyen A, Freund E, Shen S

Abstract excerpt

Embryonic stem (ES) cells isolated from late blastocysts can now be maintained in culture in an undifferentiated state provided they are grown in the presence of a specific differentiation inhibitor, known variously as leukaemia inhibiting factor (LIF) or differentiation inhibiting activity (DIA), found at high concentrations in medium conditioned by Buffalo rat liver (BRL) cells. ES cells acquired a...

Topics

Animals
Antigens, Neoplasm
Cadherins
Cell Differentiation
Embryonal Carcinoma Stem Cells
Extracellular Matrix Proteins
Growth Inhibitors
Interleukin-6
Keratins
Leukemia Inhibitory Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lewis X Antigen

Liver

Lymphokines

Mice

Neoplastic Stem Cells

Phenotype

Rats

Stem Cells

Source

Identifiers

PMID: 1698521
DOI: 10.1016/0922-3371(90)90139-n

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1698521-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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