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Article

Incomplete reactivation of<i>Oct4</i>-related genes in mouse embryos cloned from somatic nuclei

5 Mar 2003

Abstract excerpt

The majority of cloned animals derived by nuclear transfer from somatic cell nuclei develop to the blastocyst stage but die after implantation. Mouse embryos that lack an Oct4 gene, which plays an essential role in control of developmental pluripotency, develop to the blastocyst stage and also die after implantation, because they lack pluripotent embryonic cells. Based on this similarity, we posited that cloned...

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PMID: 12620990
DOI: 10.1242/dev.00366

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