Article
Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness.
The Prostate - 15 Feb 2006
Stanford Janet L, McDonnell Shannon K, Friedrichsen Danielle M, Carlson Erin E, Kolb Suzanne, Deutsch Kerry, Janer Marta, Hood Lee, Ostrander Elaine A, Schaid Daniel J
Abstract excerpt
BACKGROUND: Prostate cancer is a heterogeneous disease, both genetically and phenotypically. Linkage studies attempting to map genes for hereditary prostate cancer (HPC) have proved challenging, and one potential problem contributing to this challenge is the variability in disease phenotypes. METHODS: We collected clinical data on 784 affected men with prostate cancer from 248 HPC families for whom a genomic...
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