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Article

Allosteric communication between signal peptides and the SecA protein DEAD motor ATPase domain.

The Journal of biological chemistry - 19 Apr 2002

Baud Catherine, Karamanou Spyridoula, Sianidis Giorgos, Vrontou Eleftheria, Politou Anastasia S, Economou Anastassios

Abstract excerpt

SecA, the preprotein translocase ATPase is built of an amino-terminal DEAD helicase motor domain bound to a regulatory C-domain. SecA recognizes mature and signal peptide preprotein regions. We now demonstrate that the amino-terminal 263 residues of the ATPase subdomain of the DEAD motor are necessary and sufficient for high affinity signal peptide binding. Binding is abrogated by deletion of residues 219-244...

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Identifiers

PMID: 11825907
DOI: 10.1074/jbc.M200047200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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