Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced transcriptional activity in individuals with IL-18 gene variants detected from functional but not association study.

Biochemical and biophysical research communications - 16 Dec 2005

Liang Xiao Hui, Cheung Wai, Heng Chew Kiat, Wang De Yun

Abstract excerpt

Genetic polymorphisms of IL-18 and its receptor were reported to be associated with elevated serum IgE levels, atopy, and/or asthma. However, conflicting results were observed in various association studies and functional activity of these polymorphisms remains unclear. A total of 393 unrelated subjects were involved in this study. Direct PCR-sequencing method was used to screen novel polymorphisms. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Testing
Share to Hypersensitivity, Immediate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin E

Share to Interleukin-18

Share to Prevalence

Share to Risk Assessment

Share to Singapore

Share to Transcriptional Activation

Source

Identifiers

PMID: 16243298
DOI: 10.1016/j.bbrc.2005.10.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced transcriptional activity in individuals with IL-18 gene variants detected from functional but not association study.PMID 16243298Read ↗

Differential and opposed transcriptional effects of interleukin-18 gene polymorphisms (-137, +113, and +127) in human HepG-2, HeLa, U937, and THP-1 cells.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in the IL-18 gene with production of IL-18 protein by mononuclear cells from healthy donors.Semantic proximity Read ↗

Interleukin-18 promoter polymorphism in patients with atopic asthma.Semantic proximity Read ↗

Roles of functional polymorphisms in the interleukin-18 gene promoter in sarcoidosis.Semantic proximity Read ↗

Interleukin-18 genetics and inflammatory disease susceptibility.Semantic proximity Read ↗

A Functional Polymorphism in IL-18 Is Associated with Severity of Bronchial AsthmaSemantic proximity Read ↗

Haplotype analysis of the interleukin-18 gene in Czech patients with allergic disorders.Semantic proximity Read ↗

IL-18 gene polymorphisms affect IL-18 production capability by monocytes.Semantic proximity Read ↗

The -137G>C polymorphism in interleukin-18 promoter region and cancer risk: evidence from a meta-analysis of 21 studies.Semantic proximity Read ↗

Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation.Semantic proximity Read ↗

Effects of interleukin-18 promoter (C607A and G137C) gene polymorphisms and their association with oral squamous cell carcinoma (OSCC) in northern India.Semantic proximity Read ↗

Increased cancer risk associated with the -607C/A polymorphism in interleukin-18 gene promoter: an updated meta-analysis including 12,502 subjects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.