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Global Transcriptional Profiling Demonstrates the Combination of Type I and Type II Interferon Enhances Antiviral and Immune Responses at Clinically Relevant Doses

1 Oct 2005

Abstract excerpt

A role for type II interferon (IFN-gamma) in resolving viral infection is suggested by the correlation of hepatitis C virus (HCV) clearance with enhancement of IFN-gamma-producing activated T cells in the resolution of acute HCV infection. Using vesicular stomatitis virus (VSV), a synergistic direct antiviral effect was documented using IFN-gamma1b and a potent, consensus type I IFN (IFN alfacon-1). Global...

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PMID: 16241862
DOI: 10.1089/jir.2005.25.632

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