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Article

Mutation of serine residue 318 in the class C beta-lactamase of Enterobacter cloacae 908R.

FEMS microbiology letters - 1 Apr 1992

Jacobs C, Dubus A, Monnaie D, Normark S, Frère J M

Abstract excerpt

The involvement of the serine residue 318 in the specificity of a class C beta-lactamase was investigated. Multiple site-directed mutants at this position were generated using a polymerase chain reaction technique. These mutants were then probed for their activity towards various beta-lactam compounds. One mutant, S318G was further purified and its physico-chemical and catalytic properties determined. It was...

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Source

Identifiers

PMID: 1624116
DOI: 10.1016/0378-1097(92)90548-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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