Structure-function relationships among wild-type variants of Staphylococcus aureus beta-lactamase: importance of amino acids 128 and 216.

doi:10.1128/jb.178.24.7248-7253.1996

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Article

Structure-function relationships among wild-type variants of Staphylococcus aureus beta-lactamase: importance of amino acids 128 and 216.

Journal of bacteriology - 1 Dec 1996

Voladri R K, Tummuru M K, Kernodle D S

Abstract excerpt

beta-Lactamases inactivate penicillin and cephalosporin antibiotics by hydrolysis of the beta-lactam ring and are an important mechanism of resistance for many bacterial pathogens. Four wild-type variants of Staphylococcus aureus beta-lactamase, designated A, B, C, and D, have been identified. Al...

Topics

Alanine
Asparagine
Crystallography, X-Ray
Gene Expression
Genetic Variation
Kinetics
Serine
Staphylococcus aureus
Structure-Activity Relationship
Threonine
beta-Lactamases

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