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Article

Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation.

Journal of neuroscience research - 15 Nov 2005

Lee Sang Min, Lee Jae Woong, Song Youn Sook, Hwang Dae Youn, Kim Yong Kyu, Nam Sang Yun, Kim Dae Joong, Yun Young Won, Yoon Do Young, Hong Jin Tae

Abstract excerpt

Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with elevated ryanodine-receptor (RyR) expression and intracellular...

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PMID: 16240390
DOI: 10.1002/jnr.20655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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