Article
The P2 receptors and congenital platelet function defects.
Seminars in thrombosis and hemostasis - 1 Apr 2005
Cattaneo Marco
Abstract excerpt
Platelets possess three P2 receptors: two (P2Y (1) and P2Y (12)) are receptors for adenosine diphosphate (ADP), and one (P2X1) is a receptor for adenosine triphosphate (ATP). The P2Y (1) receptor, which is coupled to Gq and phospholipase C-beta, is responsible for mobilization of ionized calcium from internal stores and mediates the ADP-induced platelet shape change and initial wave of rapidly reversible...
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