Article
Thyroid hormone receptor beta1 in normal colon and colorectal cancer-association with differentiation, polypoid growth type and K-ras mutations.
International journal of cancer - 1 Apr 2006
Hörkkö Tuomo T, Tuppurainen Karoliina, George Susannah M, Jernvall Petra, Karttunen Tuomo J, Mäkinen Markus J
Abstract excerpt
The precursors for colorectal cancer include polypoid (conventional), flat and serrated adenomas. Polypoid growth in polypoid adenomas and serrated adenomas is associated with K-ras mutations. The regulation of polypoid or nonpolypoid growth is not well known, but could be related to trophic stimuli, such as thyroid hormones. Hence, we investigated the expression pattern of thyroid hormone receptor TRbeta1 in...
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