RET polymorphisms and sporadic medullary thyroid carcinoma in a Portuguese population.

doi:10.1385/ENDO:27:3:239

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Article

RET polymorphisms and sporadic medullary thyroid carcinoma in a Portuguese population.

Endocrine - 1 Aug 2005

Costa Patrícia, Domingues Rita, Sobrinho Luís G, Bugalho Maria João

Abstract excerpt

The genetic basis of the sporadic form of medullary thyroid carcinoma, derived from "C" cells, is still poorly understood. Somatic mutations of RET proto-oncogene have been reported at a variable frequency ranging from 23% to 69%. The hypothesis that low penetrance factors, such as polymorphisms, might contribute to the phenotype of this neoplasm has been addressed in a few studies conducting to conflicting...

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PMID: 16230779
DOI: 10.1385/ENDO:27:3:239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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