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Long-Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2026

Guo Jianhui, Zhong Xia, Koutrakis Petros, Vieira Carolina L Zilli, Si Feifei, Wang Yaqi, Lian Xinyao, Fan Yi, Wang Zhaokun, Huang Shaodan, Li Jing

Abstract excerpt

Benzene is a common urban air pollutant with potential neurotoxicity, yet the health effects of long-term, low-level ambient exposure and the underlying mechanisms remain poorly characterized. Here, we used data from 288,180 UK Biobank (UKB) participants to investigate associations between benzene exposure and brain disorders as well as related genetic susceptibility and potential protein-mediated mechanisms. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42213015
DOI: 10.1002/advs.75874
PMCID: PMC13336048

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