Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Site-directed mutagenesis and structural modeling of Coq10p indicate the presence of a tunnel for coenzyme Q6 binding.

FEBS letters - 16 Apr 2010

Busso Cleverson, Bleicher Lucas, Ferreira-Júnior José Ribamar, Barros Mario H

Abstract excerpt

Coq10p is a protein required for coenzyme Q function, but its specific role is still unknown. It is a member of the START domain superfamily that contains a hydrophobic tunnel implicated in the binding of lipophilic molecules. We used site-directed mutagenesis, statistical coupling analysis and molecular modeling to probe structural determinants in the Coq10p putative tunnel. Four point mutations were generated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Respiration

Share to Hydrophobic and Hydrophilic Interactions

Share to Models, Molecular

Share to Mutagenesis, Site-Directed

Share to Protein Conformation

Share to Ubiquinone

Source

Identifiers

PMID: 20303962
DOI: 10.1016/j.febslet.2010.03.024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Site-directed mutagenesis and structural modeling of Coq10p indicate the presence of a tunnel for coenzyme Q6 binding.PMID 20303962Read ↗

The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration.Semantic proximity Read ↗

Coq10, a mitochondrial coenzyme Q binding protein, is required for proper respiration in Schizosaccharomyces pombe.Semantic proximity Read ↗

The COQ2 genotype predicts the severity of coenzyme Q10 deficiency.Semantic proximity Read ↗

A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease.Semantic proximity Read ↗

Coq7p relevant residues for protein activity and stability.Semantic proximity Read ↗

AlphaFold Structure Analysis of COQ2 as Key Component of the Coenzyme Q Synthesis ComplexSemantic proximity Read ↗

A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency.Semantic proximity Read ↗

Effect of vanillic acid on COQ6 mutants identified in patients with coenzyme Q10 deficiency.Semantic proximity Read ↗

The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis.Semantic proximity Read ↗

Fatal neonatal encephalopathy and lactic acidosis caused by a homozygous loss-of-function variant in COQ9.Semantic proximity Read ↗

Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis.Semantic proximity Read ↗

Coq6 is responsible for the C4-deamination reaction in coenzyme Q biosynthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.