Article
Novel locus for an inherited cardiomyopathy maps to chromosome 7.
Circulation - 9 May 2006
Song Lei, DePalma Steven R, Kharlap Maria, Zenovich Andrey G, Cirino Allison, Mitchell Richard, McDonough Barbara, Maron Barry J, Seidman Christine E, Seidman J G, Ho Carolyn Y
Abstract excerpt
BACKGROUND: Genetic mutations are the most common cause of hypertrophic cardiomyopathy (HCM) and an increasingly recognized cause of dilated cardiomyopathy. Autosomal dominant HCM is caused by mutations in sarcomere proteins; such mutations are not universally present, however, and fail to account for &40% of cases of phenotypic HCM. To add further complexity, other genetic origins can mimic the gross clinical...
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