Article
The stromal derived factor-1 mutated allele (SDF1-3'A) is associated with a lower incidence of atherosclerosis in HIV-infected patients.
AIDS (London, England) - 4 Nov 2005
Coll Blai, Alonso-Villaverde Carlos, Parra Sandra, Montero Manuel, Tous Monica, Joven Jorge, Masana Lluis
Abstract excerpt
BACKGROUND: HIV-infected patients have higher rates of subclinical atherosclerosis. The chemokine stromal derived factor 1 (SDF-1) is the natural ligand for the CXCR4 HIV co-receptor, is highly expressed in atherosclerotic plaques, and the plasma concentration is lower in individuals homozygous for the mutant allele (SDF1-3'A). We tested the influence of SDF1-3'A on atherosclerosis in HIV-infected patients....
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